Effects of Gaseous Anesthetics Nitrous Oxide and Xenon on Ligand-gated Ion Channels: Comparison with Isoflurane and Ethanol

@article{Yamakura2000EffectsOG,
  title={Effects of Gaseous Anesthetics Nitrous Oxide and Xenon on Ligand-gated Ion Channels: Comparison with Isoflurane and Ethanol},
  author={Tomohiro Yamakura and R. Adron Harris},
  journal={Anesthesiology},
  year={2000},
  volume={93},
  pages={1095-1101}
}
BackgroundLigand-gated ion channels are considered to be potential general anesthetic targets. Although most general anesthetics potentiate the function of &ggr;-aminobutyric acid receptor type A (GABAA), the gaseous anesthetics nitrous oxide and xenon are reported to have little effect on GABAA receptors but inhibit N-methyl-d-aspartate (NMDA) receptors. To define the spectrum of effects of nitrous oxide and xenon on receptors thought to be important in anesthesia, the authors tested these… 

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