Effects of Gabexate Mesilate, a Protease Inhibitor, on Human Sphincter of Oddi Motility

@article{Francesco2002EffectsOG,
  title={Effects of Gabexate Mesilate, a Protease Inhibitor, on Human Sphincter of Oddi Motility},
  author={Vincenzo Di Francesco and Alberto Mariani and Giampaolo Angelini and Enzo Masci and Luca Frulloni and Giorgio Talamini and Sandro Passaretti and Pieralberto Testoni and Giorgio Cavallini},
  journal={Digestive Diseases and Sciences},
  year={2002},
  volume={47},
  pages={741-745}
}
Gabexate mesilate is an antiprotease drug, which reduced the severity of pancreatitis and frequency of post-ERCP pancreatitis. In dogs gabexate inhibits sphincter of Oddi motility but no data are available in humans. The aim of this study was to verify by manometry the action of gabexate on human sphincter of Oddi motility. We enrolled 12 patients with idiopathic recurrent pancreatitis (eight males, five females, mean age 46 ± 8 years). Standard preendoscopic sphincter of Oddi manometry was… CONTINUE READING

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