Effects of GH secretagogues on contractility and Ca2+ homeostasis of isolated adult rat ventricular myocytes.

@article{Sun2010EffectsOG,
  title={Effects of GH secretagogues on contractility and Ca2+ homeostasis of isolated adult rat ventricular myocytes.},
  author={Qingnan Sun and Yi Fei Ma and Lin Zhang and Yu-feng Zhao and Wei-jin Zang and Chen T. Chen},
  journal={Endocrinology},
  year={2010},
  volume={151 9},
  pages={4446-54}
}
Ghrelin and its synthetic analogue hexarelin are specific ligands of GH secretagogue receptor (GHS-R) and induce a variety of cardiovascular protective and cardiac positive inotropic effects. The signaling system underlying immediate effects of both GHSs in cardiomyocytes remains undefined. In the present study, we investigated the immediate effects of GHSs on isolated ventricular myocyte shortening, intracellular Ca(2+) ([Ca(2+)](i)) transients, and the L-type Ca(2+) current (I(Ca,L… CONTINUE READING

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