Effects of GBR 12909, a selective dopamine uptake inhibitor, on motor activity and operant behavior in the rat.

@article{Kelley1989EffectsOG,
  title={Effects of GBR 12909, a selective dopamine uptake inhibitor, on motor activity and operant behavior in the rat.},
  author={Ann Elise Kelley and Christopher G. Lang},
  journal={European journal of pharmacology},
  year={1989},
  volume={167 3},
  pages={
          385-95
        }
}
GBR 12909, an aryl 1,4-dialkylpiperazine derivative, is a potent and selective inhibitor of the presynaptic dopamine uptake complex. The behavioral effects of this compound were studied in rats using several different paradigms. GBR 12909 (1, 10, 20 mg/kg i.p.) elicited a dose-dependent, long-lasting behavioral activation characterized by locomotion, rearing, sniffing and stereotypies at the highest dose. A second experiment investigated the consequences of subchronic treatment (one injection… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 29 CITATIONS

Transgenerational Sequelae of Acute Antenatal Stress in Pregnant Rats

  • Neuroscience and Behavioral Physiology
  • 2013
VIEW 5 EXCERPTS
CITES METHODS
HIGHLY INFLUENCED