Effects of GABAergic agents on anesthesia induced by halothane, isoflurane, and thiamylal in mice

@article{Sugimura2002EffectsOG,
  title={Effects of GABAergic agents on anesthesia induced by halothane, isoflurane, and thiamylal in mice},
  author={M. Sugimura and S. Kitayama and K. Morita and Y. Imai and T. Dohi},
  journal={Pharmacology Biochemistry and Behavior},
  year={2002},
  volume={72},
  pages={111-116}
}
The effects of gamma-aminobutyric acid (GABA) receptor modulators and GABA uptake inhibitors on volatile and intravenous anesthetic-induced anesthesia were examined in male ICR mice, as assessed by the loss of righting reflex (LORR). The GABA uptake inhibitors, NO-711 and SKF89976A, which are permeable to the blood-brain barrier (BBB), but not nipecotic acid or guvacine, which poorly permeate BBB, shortened the onset of LORR but did not affect the duration of LORR induced by 1.5% halothane and… Expand
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