Effects of GABAB receptor ligands in animal tests of depression and anxiety.

@article{Frankowska2007EffectsOG,
  title={Effects of GABAB receptor ligands in animal tests of depression and anxiety.},
  author={Małgorzata Frankowska and Małgorzata Filip and Edmund Przegaliński},
  journal={Pharmacological reports : PR},
  year={2007},
  volume={59 6},
  pages={645-55}
}
Preclinical evidence strongly implicates GABA(B) receptors in the pathophysiology of several psychiatric disorders including anxiety and depression. In the present study, we investigated the effects of the selective GABA(B) receptor agonists baclofen and SKF 97541, the GABA(B) receptor positive allosteric modulator CGP7930 and the GABA(B) receptor antagonist SCH 50911 in the modified forced swimming test (FST) and in the elevated zero maze test (EZM), i.e. in animal models predictive of… CONTINUE READING