Effects of GABA antagonists and habituation to novelty on ethanol-induced locomotor activity in mice.

Abstract

The effects of the gamma-aminobutyric acid (GABA) antagonists picrotoxin and bicuculline on ethanol-induced motor excitation were assessed on habituated and non-habituated mice. Habituated mice were exposed to the testing apparatus for 30 min on 4 consecutive days before testing. Mice were treated with several doses of ethanol (0.8, 1.2 and 1.6 g/kg… (More)

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