Effects of G/A polymorphism, rs266882, in the androgen response element 1 of the PSA gene on prostate cancer risk, survival and circulating PSA levels

@article{Jesser2008EffectsOG,
  title={Effects of G/A polymorphism, rs266882, in the androgen response element 1 of the PSA gene on prostate cancer risk, survival and circulating PSA levels},
  author={Christine Jesser and Lorelei A. Mucci and Diana Farmer and Chulso Moon and Haiyue Li and J. Michael Gaziano and Meir Jonathan Stampfer and Jing Ma and Philip W. Kantoff},
  journal={British Journal of Cancer},
  year={2008},
  volume={99},
  pages={1743 - 1747}
}
Prostate-specific antigen (PSA) is a protease produced in the prostate that cleaves insulin-like growth factor binding protein-3 and other proteins. Production is mediated by the androgen receptor (AR) binding to the androgen response elements (ARE) in the promoter region of the PSA gene. Studies of a single nucleotide polymorphism (PSA −158 G/A, rs266882) in ARE1 of the PSA gene have been conflicting for risk of prostate cancer and effect on plasma PSA levels. In this nested case–control… CONTINUE READING
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