Effects of Food on a Gastrically Degraded Drug: Azithromycin Fast-Dissolving Gelatin Capsules and HPMC Capsules

@article{Curatolo2011EffectsOF,
  title={Effects of Food on a Gastrically Degraded Drug: Azithromycin Fast-Dissolving Gelatin Capsules and HPMC Capsules},
  author={William Curatolo and Ping Liu and Barbara A. Johnson and Angela Hausberger and Ernest Quan and Thomas Vendola and Neha B. Vatsaraj and George Foulds and J. -D. Vincent and Richa S Chandra},
  journal={Pharmaceutical Research},
  year={2011},
  volume={28},
  pages={1531-1539}
}
Commercial azithromycin gelatin capsules (Zithromax®) are known to be bioequivalent to commercial azithromycin tablets (Zithromax®) when dosed in the fasted state. These capsules exhibit a reduced bioavailability when dosed in the fed state, while tablets do not. This gelatin capsule negative food effect was previously proposed to be due to slow and/or delayed capsule disintegration in the fed stomach, resulting in extended exposure of the drug to gastric acid, leading to degradation to des… CONTINUE READING

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