Effects of Focal Cerebral Ischemia on Exosomal Versus Serum miR126

@article{Chen2015EffectsOF,
  title={Effects of Focal Cerebral Ischemia on Exosomal Versus Serum miR126},
  author={Fan Chen and Yang Du and Elga Esposito and Yi Liu and Shuzhen Guo and Xiaoying Wang and Eng H. Lo and Changhong Xing and Xunming Ji},
  journal={Translational Stroke Research},
  year={2015},
  volume={6},
  pages={478-484}
}
Emerging data suggest that exosomal microRNA (miRNA) may provide potential biomarkers in acute ischemic stroke. However, the effects of ischemia-reperfusion on total versus exosomal miRNA responses in circulating blood remain to be fully defined. Here, we quantified levels of miR-126 in whole serum versus exosomes extracted from serum and compared these temporal profiles against reperfusion and outcomes in a rat model of acute focal cerebral ischemia. First, in vitro experiments confirmed the… CONTINUE READING

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