Effects of Flt3 ligand and interleukin-7 on in vitro growth of acute lymphoblastic leukemia cells.

@article{Eder1996EffectsOF,
  title={Effects of Flt3 ligand and interleukin-7 on in vitro growth of acute lymphoblastic leukemia cells.},
  author={Matthias Eder and Philipp Guido Hemmati and Uwe Kalina and O G Ottman and Dieter Hoelzer and S. D. Lyman and Arnold Ganser},
  journal={Experimental hematology},
  year={1996},
  volume={24 2},
  pages={371-7}
}
We investigated the effects of Flt3/Flk-2 ligand (FL) and interleukin-7 (IL-7) on DNA synthesis and proliferation of blast cells from patients with acute lymphoblastic leukemia (ALL). After 7 days of serum-free suspension culture of 19 samples, FL induced maximal DNA synthesis in two cases, whereas the combination of FL and IL-7 did so in another eight samples with a stimulation index (SI) >2. However, the number of viable cells after 7 days of liquid culture decreased in all but one sample. In… CONTINUE READING
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