Effects of FSH on testicular mRNA transcript levels in the hypogonadal mouse

@inproceedings{Abel2009EffectsOF,
  title={Effects of FSH on testicular mRNA transcript levels in the hypogonadal mouse},
  author={Margaret H. Abel and Dilair F. Baban and Sang-Hee Lee and Harry M. Charlton and Peter O'Shaughnessy},
  booktitle={Journal of molecular endocrinology},
  year={2009}
}
FSH acts through the Sertoli cell to ensure normal testicular development and function. To identify transcriptional mechanisms through which FSH acts in the testis, we have treated gonadotrophin-deficient hypogonadal (hpg) mice with recombinant FSH and measured changes in testicular transcript levels using microarrays and real-time PCR 12, 24 and 72 h after the start of treatment. Approximately 400 transcripts were significantly altered at each time point by FSH treatment. At 12 h, there was a… CONTINUE READING