Effects of FPL-52694, a new mast cell stabilizer, on gastric secretion and various acute gastric lesions in rats

@article{Takeuchi1984EffectsOF,
  title={Effects of FPL-52694, a new mast cell stabilizer, on gastric secretion and various acute gastric lesions in rats},
  author={Koji Takeuchi and Yoko Ishihara and Haruyo Kunimi and Susumu Okabe},
  journal={Agents and Actions},
  year={1984},
  volume={14},
  pages={637-642}
}
Oral FPL-52694 [5-(2-hydroxypropoxy)-8-propyl-4-oxo-4H-1-benzopyran-2-carboxylic acid Na], a new mast cell stabilizer, dose-dependently inhibited gastric acid secretion but increased the volume and pepsin output in pylorus-ligated rats. Intraduodenal FPL-52694 significantly inhibited all of the volume, acidity, acid output and pepsin output. Concerning the acidity, oral administration of the agent showed much more potent inhibition than intraduodenal administration. Oral FPL-52694 markedly… CONTINUE READING