Effects of FGFs on the morphogenic potency and AER-maintenance activity of cultured progress zone cells of chick limb bud.

@article{Hara1998EffectsOF,
  title={Effects of FGFs on the morphogenic potency and AER-maintenance activity of cultured progress zone cells of chick limb bud.},
  author={Kenji Hara and Jun Kimura and Hiroyuki Ide},
  journal={The International journal of developmental biology},
  year={1998},
  volume={42 4},
  pages={591-9}
}
The apical mesodermal region of chick limb buds (progress zone, PZ) which is essential for limb pattern formation contains uncommitted cells that change their positional values instructed by the apical ectodermal ridge (AER). Reciprically, the PZ cells maintain the AER activity. FGF-2 and FGF-4 can substitute for the AER to maintain normal outgrowth and gene expression in the limb bud. We examined the effects of FGF on the maintenance of PZ cells characteristics in culture by making recombinant… CONTINUE READING

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