Effects of Extracorporeal Shock Wave-Mediated Transdermal Local Anesthetic Drug Delivery on Rat Caudal Nerves.

@article{Luh2018EffectsOE,
  title={Effects of Extracorporeal Shock Wave-Mediated Transdermal Local Anesthetic Drug Delivery on Rat Caudal Nerves.},
  author={Jer-Junn Luh and Wan-Ting Huang and Kwan-Hwa Lin and Yi-you Huang and Po-Ling Kuo and Wen-shiang Chen},
  journal={Ultrasound in medicine & biology},
  year={2018},
  volume={44 1},
  pages={
          214-222
        }
}
Cavitation plays a substantial role in the clinical effects of extracorporeal shock wave therapy (ESWT). It is also generally accepted as a major mechanism in sonophoresis. To identify the enhancing effect of extracorporeal shock wave-mediated transdermal drug delivery, 24 Wistar rats were randomly assigned to four groups: (i) topical application of a eutectic mixture of local anesthetics (EMLA); (ii) 1-MHz ultrasound; (iii) ESWT pre-treatment combined with EMLA application; (iv) ESWT… CONTINUE READING
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