Effects of Eugenol, an Essential Oil, on the Mechanical and Electrical Activities of Cardiac Muscle

  title={Effects of Eugenol, an Essential Oil, on the Mechanical and Electrical Activities of Cardiac Muscle},
  author={C. E. N. Damiani and C. Moreira and H. Zhang and T. Creazzo and D. Vassallo},
  journal={Journal of Cardiovascular Pharmacology},
  • C. E. N. Damiani, C. Moreira, +2 authors D. Vassallo
  • Published 2004
  • Chemistry, Medicine
  • Journal of Cardiovascular Pharmacology
  • Eugenol (EUG) acts as a calcium antagonist but effects on the contractile proteins could also occur. We investigated inotropic effects of EUG in rat left ventricular papillary muscles, measuring isometric force, time variables, and post rest potentiation and EUG actions on the effects of Ca2+ (0.62 to 2.5 mM) and isoproterenol (5 ng/ml), on myosin ATPase activity and on the calcium currents in single ventricular myocytes. EUG reduced tension and time variables without altering the sarcoplasmic… CONTINUE READING
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