Effects of Esomeprazole on the Pharmacokinetics of Lapatinib in Breast Cancer Patients.

Abstract

The aqueous solubility of lapatinib declines significantly at pH >4, suggesting that its bioavailability might be lowered by acid-reducing drugs. A study was therefore conducted to assess the effects of esomeprazole on lapatinib pharmacokinetics (PK). Women with metastatic human epidermal growth factor receptor 2 positive (HER2(+) ) breast cancer were… (More)
DOI: 10.1002/cpdd.45

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Cite this paper

@article{Koch2013EffectsOE, title={Effects of Esomeprazole on the Pharmacokinetics of Lapatinib in Breast Cancer Patients.}, author={Kevin M. Koch and Young Hyuk Im and Sung Bae Kim and Ander Urruticoechea Ribate and Joe J. Stephenson and Jeffrey D. Botbyl and Leanne Cartee and J Warren Holshouser and Derry Ridgway}, journal={Clinical pharmacology in drug development}, year={2013}, volume={2 4}, pages={336-41} }