Effects of Escherichia coli heat-stable enterotoxin STb on intestines of mice, rats, rabbits, and piglets.

@article{Kennedy1984EffectsOE,
  title={Effects of Escherichia coli heat-stable enterotoxin STb on intestines of mice, rats, rabbits, and piglets.},
  author={David J. Kennedy and Richard N. Greenberg and John A. Dunn and Robert Abernathy and Jan Stephen Ryerse and Richard Littleton Guerrant},
  journal={Infection and immunity},
  year={1984},
  volume={46 3},
  pages={639-43}
}
There are at least two classes of Escherichia coli heat-stable enterotoxins, STa and STb. Unlike STa, which is active in suckling mice and piglets, STb is inactive in suckling mice but active in piglets and older, weaned pigs. This study examined the activity of STb in several animals and its effect on intestinal histology and cyclic GMP levels in intestinal mucosal cells. STb did not cause fluid secretion in suckling mice up to 12 days old or in rat or rabbit intestinal-loop preparations. STb… CONTINUE READING

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