Effects of Electroacupuncture at BL60 on Formalin-Induced Pain in Rats

@article{Chang2012EffectsOE,
  title={Effects of Electroacupuncture at BL60 on Formalin-Induced Pain in Rats},
  author={Kyung Ha Chang and Ran Won and Insop Shim and Hye-jeong Lee and Bae Hwan Lee},
  journal={Evidence-based Complementary and Alternative Medicine : eCAM},
  year={2012},
  volume={2012}
}
  • K. Chang, R. Won, +2 authors B. Lee
  • Published 5 April 2012
  • Medicine
  • Evidence-based Complementary and Alternative Medicine : eCAM
Acupuncture was used to treat symptoms of pain in the ancient orient. The present study was conducted to determine the effects of electroacupuncture (EA) at the BL60 acupoint on male Sprague-Dawley rats. Each rat received EA at BL60 acupoint before formalin injection. Behavioral responses were recorded using a video camera and c-Fos immunohistochemistry was performed thereafter. Treatment of EA at BL60 significantly inhibited flinching behavior and c-fos expression induced by formalin injection… 
Effects of Acupuncture Stimulation at Different Acupoints on Formalin-Induced Pain in Rats
  • K. Chang, S. Bai, Hye-jeong Lee, B. Lee
  • Medicine
    The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology
  • 2014
TLDR
It is suggested that acupuncture especially at the BL60 ac upoint is more effective in relieving inflammatory pain than other acupoints.
Mechanisms of Acupuncture–Electroacupuncture on Persistent Pain
TLDR
Electroacupuncture activates the nervous system differently in health than in pain conditions, alleviates both sensory and affective inflammatory pain, and inhibits inflammatory and neuropathic pain more effectively at 2 to 10 Hz than at 100 Hz.
Electroacupuncture Inhibition of Hyperalgesia in Rats with Adjuvant Arthritis: Involvement of Cannabinoid Receptor 1 and Dopamine Receptor Subtypes in Striatum
TLDR
Results suggested that the strong activation of the CB1 receptor after repeated EA resulted in the concomitant phenomenon of the upregulation of D1 and D2 levels of gene expression.
Inhibition of Spinal Interlukin-33/ST2 Signaling and Downstream ERK and JNK Pathways in Electroacupuncture Analgesia in Formalin Mice
TLDR
The data suggest that EA alleviates formalin-induced inflammatory pain, at least partially, by inhibiting of spinal IL-33/ST2 signaling and the downstream ERK and JNK pathways.
Antinociceptive Effects of Spinal Manipulative Therapy on Nociceptive Behavior of Adult Rats during the Formalin Test
TLDR
Administration of LVVA-SM had a short-term, remote antinociceptive effect similar to clinical findings, and mechanistic investigations using this experimental approach are warranted.
Modulation of Brain Electroencephalography Oscillations by Electroacupuncture in a Rat Model of Postincisional Pain
  • J. Wang, J. Wang, +4 authors Y. Wan
  • Medicine
    Evidence-based complementary and alternative medicine : eCAM
  • 2013
TLDR
This study is the first time to describe that brain oscillations are correlated with the processing of spontaneous pain information in postincisional pain model of rats, and EA could regulate these brain rhythmical frequency oscillations, including the power and cross-frequency couplings.
Acupuncture mechanisms: Anesthesia, analgesia and protection on organ functions
TLDR
The current evidence supports that acupuncture analgesia and its organ protection in anesthesia is associated with the integration of neuroendocrine-immune networks in the level of neurotransmitters, cytokines, hormones, neuronal ensembles, lymphocytes, and endocrine cells.
Differential Localization of Pain-Related and Pain-Unrelated Neural Responses for Acupuncture at BL60 Using BOLD fMRI
TLDR
Pre-anesthetic verum acupuncture at BL60 activated areas of vision and pain transmission and deactivated brain areas of visual function, which indicates that specific effects of acupoint BL60 are to control vision sense as used in the clinical setting.
In vivo anti-inflammatory, analgesic and antipyretic effects of dichloromethane stem bark extract of Acacia mellifera in mice and rat models
Inflammation is a reaction to irritants that causes an injury to the body. Pain is a physical discomfort caused by injury or illness while pyrexia is an increase in body temperature above the normal
Research advances in treatment of neurological and psychological diseases by acupuncture at the Acupuncture Meridian Science Research Center
TLDR
It is strongly believed that these effects, evident from the AMSRC research results, can play leading roles in the use of acupuncture for treating neurological diseases, based on collaboration among various academic fields such as neurophysiology, molecular genetics, and traditional Korean medicine.
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