Effects of Efflux Pump Inhibitors on Colistin Resistance in Multidrug-Resistant Gram-Negative Bacteria.

@article{Ni2016EffectsOE,
  title={Effects of Efflux Pump Inhibitors on Colistin Resistance in Multidrug-Resistant Gram-Negative Bacteria.},
  author={Wentao Ni and Yanjun Li and Jie Guan and Jin Zhao and Junchang Cui and Rui Wang and You-ning Liu},
  journal={Antimicrobial agents and chemotherapy},
  year={2016},
  volume={60 5},
  pages={3215-8}
}
We tested the effects of various putative efflux pump inhibitors on colistin resistance in multidrug-resistant Gram-negative bacteria. Addition of 10 mg/liter cyanide 3-chlorophenylhydrazone (CCCP) to the test medium could significantly decrease the MICs of colistin-resistant strains. Time-kill assays showed CCCP could reverse colistin resistance and inhibit the regrowth of the resistant subpopulation, especially in Acinetobacter baumannii and Stenotrophomonas maltophilia These results suggest… CONTINUE READING