Effects of ETV5 (ets variant gene 5) on testis and body growth, time course of spermatogonial stem cell loss, and fertility in mice.

@article{Schlesser2008EffectsOE,
  title={Effects of ETV5 (ets variant gene 5) on testis and body growth, time course of spermatogonial stem cell loss, and fertility in mice.},
  author={Heather N Schlesser and Liz Simon and M C Hofmann and Kenneth M Murphy and Theresa Murphy and Rex Allen Hess and Paul S. Cooke},
  journal={Biology of reproduction},
  year={2008},
  volume={78 3},
  pages={483-9}
}
The transcription factor ets variant gene 5 (ETV5; also known as ERM) is essential for self-renewal of spermatogonial stem cells (SSCs). Mice with targeted disruption of Etv5 (Etv5(-/-)) undergo the first wave of spermatogenesis, but all SSCs are lost during this time, causing a Sertoli cell-only phenotype. This study examined body and testis growth and the time course of SSC loss in Etv5(-/-) mice to understand how loss of ETV5 impacts testicular and somatic development. Body weights were… CONTINUE READING
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