Effects of E. coli sepsis and myocardial depressant factor on interval-force relations in dog ventricle.

@article{Jha1993EffectsOE,
  title={Effects of E. coli sepsis and myocardial depressant factor on interval-force relations in dog ventricle.},
  author={Pratik D Jha and Hans Jacobs and Deepak Bose and Run Ming Wang and J J Yang and Richard B. Light and Steven N. Mink},
  journal={The American journal of physiology},
  year={1993},
  volume={264 5 Pt 2},
  pages={H1402-10}
}
We examined whether depressed left ventricular (LV) contractility during Escherichia coli sepsis in dogs was due to a decrease in the fractional release of calcium from the sarcoplasmic reticulum (SR) or a reduction in calcium content in this organelle. To indirectly assess SR calcium availability in a right ventricular (RV) trabecular muscle preparation, we utilized functional indexes of cellular myocardial calcium metabolism, which included rapid-cooling contracture (RCC), an indicator of SR… CONTINUE READING