Effects of Dopexamine on Creatinine Clearance, Systemic Inflammation, and Splanchnic Oxygenation in Patients Undergoing Coronary Artery Bypass Grafting

@article{Berendes1997EffectsOD,
  title={Effects of Dopexamine on Creatinine Clearance, Systemic Inflammation, and Splanchnic Oxygenation in Patients Undergoing Coronary Artery Bypass Grafting},
  author={Elmar Berendes and Th. M{\"o}llhoff and h c Hugo Van Aken and Christoph Stephan Schmidt and Michael Erren and Mario C Deng and Michael Weyand and H. M. Loick},
  journal={Anesthesia and analgesia},
  year={1997},
  volume={84 5},
  pages={
          950-7
        }
}
Impairment of splanchnic and peripheral tissue perfusion during cardiopulmonary bypass (CPB) may be responsible for endotoxin-mediated systemic inflammation and acute phase responses. We examined the effects of dopexamine on hemodynamic parameters, creatinine clearance, systemic and splanchnic oxygenation, gastric mucosal pH (pHi), and mixed and hepatic venous plasma levels of endotoxin, interleukin-6 (IL-6), serum amyloid A (SAA), and C-reactive protein (CRP) in 44 patients scheduled for… CONTINUE READING