Effects of Dietary Pyrazinamide, an Antituberculosis Agent, on the Metabolism of Tryptophan to Niacin and of Tryptophan to Serotonin in Rats

@article{Shibata2001EffectsOD,
  title={Effects of Dietary Pyrazinamide, an Antituberculosis Agent, on the Metabolism of Tryptophan to Niacin and of Tryptophan to Serotonin in Rats},
  author={Katsumi Shibata and Tsutomu Fukuwatari and Etsuro Sugimoto},
  journal={Bioscience, Biotechnology, and Biochemistry},
  year={2001},
  volume={65},
  pages={1339 - 1346}
}
The effects of pyrazinamide on the metabolism of tryptophan to niacin and of tryptophan to serotonin were investigated to elucidate the mechanism for pyrazinamide action against tuberculosis. Weanling rats were fed with a diet with or without 0.25% pyrazinamide for 61 days. Urine samples were periodically collected for measuring the tryptophan metabolites. The administration of pyrazinamide significantly increased the metabolites, 3-hydroxyanthranilic acid and beyond, especially quinolinic acid… 
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Results suggest that a derivative of POA metabolized by rats inhibited the ACMSD activity, the rate-limiting enzyme in the tryptophan-niacin pathway.
Effects of Fatty Liver Induced by Niacin-free Diet with Orotic Acid on the Metabolism of Tryptophan to Niacin in Rats
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The conversion ratio of tryptophan to niacin significantly decreased in the test group in comparison with the control group, and the concentrations of NAD and NADP in liver significantly decreased, while these in blood did not decrease compared to thecontrol group.
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Effects of Excess Nicotinamide Administration on the Urinary Excretion of Nicotinamide N-Oxide and Nicotinuric Acid by Rats
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TLDR
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Organ Co-Relationship in Tryptophan Metabolism and Factors That Govern the Biosynthesis of Nicotinamide from Tryptophan.
  • K. Shibata
  • Biology, Chemistry
    Journal of nutritional science and vitaminology
  • 2018
TLDR
The findings indicate that QPRT is not the rate-limiting enzyme in the conversion of Trp to nicotinamide, and the limiting factors in the Conversion are the amounts of 3-hydroxyanthranilic acid and quinolinic acid in the liver and the activity of liver 3-Hydroxyanic acid 3,4-dioxygenase.
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It is suggested that the conversion of nicotinamide from tryptophan is important in maintaining niacin nutrition and contributed to the determination of dietary reference intakes for niacIn recommended in the Dietary Reference Intakes for Japanese 2010.
Changes in the urinary excretion of the metabolites of the tryptophan-niacin pathway during pregnancy in Japanese women and rats.
TLDR
The urinary excretions of niacin metabolites in humans and rats increased from mid pregnancy in a time-dependent manner, reached a peak of 2-3-fold during late pregnancy, and declined to control levels after childbirth.
Antioxidant and hepatoprotective effect of Macrotyloma uniflorum seed in antitubercular drug induced liver injury in rats
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The present findings indicate that the hepatoprotective effect of GIE in ATD–induced oxidative damage may be due to its antioxidant activity.
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