Effects of Dietary Pyrazinamide, an Antituberculosis Agent, on the Metabolism of Tryptophan to Niacin and of Tryptophan to Serotonin in Rats

@article{Shibata2001EffectsOD,
  title={Effects of Dietary Pyrazinamide, an Antituberculosis Agent, on the Metabolism of Tryptophan to Niacin and of Tryptophan to Serotonin in Rats},
  author={Katsumi Shibata and Tsutomu Fukuwatari and Etsuro Sugimoto},
  journal={Bioscience, Biotechnology, and Biochemistry},
  year={2001},
  volume={65},
  pages={1339 - 1346}
}
The effects of pyrazinamide on the metabolism of tryptophan to niacin and of tryptophan to serotonin were investigated to elucidate the mechanism for pyrazinamide action against tuberculosis. Weanling rats were fed with a diet with or without 0.25% pyrazinamide for 61 days. Urine samples were periodically collected for measuring the tryptophan metabolites. The administration of pyrazinamide significantly increased the metabolites, 3-hydroxyanthranilic acid and beyond, especially quinolinic acid… 
Growth-promoting Activity of Pyrazinoic Acid, a Putative Active Compound of Antituberculosis Drug Pyrazinamide, in Niacin-deficient Rats through the Inhibition of ACMSD Activity
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Results suggest that a derivative of POA metabolized by rats inhibited the ACMSD activity, the rate-limiting enzyme in the tryptophan-niacin pathway.
Effects of Fatty Liver Induced by Niacin-free Diet with Orotic Acid on the Metabolism of Tryptophan to Niacin in Rats
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The conversion ratio of tryptophan to niacin significantly decreased in the test group in comparison with the control group, and the concentrations of NAD and NADP in liver significantly decreased, while these in blood did not decrease compared to thecontrol group.
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TLDR
The aim of the present workshop was to identify biomarkers that could be used before the appearance of adverse effects of L-Trp, and it is shown that the urinary excretory ratio of anthranilic acid:kynurenic acid is potentially the most sensitive and appropriate surrogate breakpoint index to predict the UL.
Organ Co-Relationship in Tryptophan Metabolism and Factors That Govern the Biosynthesis of Nicotinamide from Tryptophan.
  • K. Shibata
  • Chemistry, Medicine
    Journal of nutritional science and vitaminology
  • 2018
TLDR
The findings indicate that QPRT is not the rate-limiting enzyme in the conversion of Trp to nicotinamide, and the limiting factors in the Conversion are the amounts of 3-hydroxyanthranilic acid and quinolinic acid in the liver and the activity of liver 3-Hydroxyanic acid 3,4-dioxygenase.
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TLDR
It is suggested that the conversion of nicotinamide from tryptophan is important in maintaining niacin nutrition and contributed to the determination of dietary reference intakes for niacIn recommended in the Dietary Reference Intakes for Japanese 2010.
Changes in the urinary excretion of the metabolites of the tryptophan-niacin pathway during pregnancy in Japanese women and rats.
TLDR
The urinary excretions of niacin metabolites in humans and rats increased from mid pregnancy in a time-dependent manner, reached a peak of 2-3-fold during late pregnancy, and declined to control levels after childbirth.
Antioxidant and hepatoprotective effect of Macrotyloma uniflorum seed in antitubercular drug induced liver injury in rats
Horse gram [Macrotyloma uniflorum Lam. (Verdc.)] is a lesser known bean consumed as a whole seed or sprout in India. Its seeds are rich in flavonoids and phenolic acids. The protective effect of a
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