Effects of Dehydroepiandrosterone Sulfate on Blood Pressure and Aldosterone Level via μ-Opioid Receptors

@article{Obut2013EffectsOD,
  title={Effects of Dehydroepiandrosterone Sulfate on Blood Pressure and Aldosterone Level via μ-Opioid Receptors},
  author={Timofey Obut and M. V. Ovsukova and T. A. Erdinieva and E. T. Obut and T. Yu. Dement’eva and S. A. Egorova and Vladimir A. Kozlov},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2013},
  volume={156},
  pages={35-37}
}
Dehydroepiandrosterone sulfate (30 mg/kg) produced a hypotensive effect by preventing stress-induced surge of hypertensive hormone aldosterone in rats after manifold repeated, but not single stress exposure. Both effects were realized via μ-opioid receptors. Thus, μ-opioid mechanism of blockage of aldosterone surge can underlay the hypotensive effects of… CONTINUE READING