Effects of DNA adduct structure and distribution on the mutagenicity and genotoxicity of two platinum anticancer drugs.

@article{Yarema1994EffectsOD,
  title={Effects of DNA adduct structure and distribution on the mutagenicity and genotoxicity of two platinum anticancer drugs.},
  author={Kevin J. Yarema and James Michael Wilson and Stephen J Lippard and John M Essigmann},
  journal={Journal of molecular biology},
  year={1994},
  volume={236 4},
  pages={1034-48}
}
cis-Diamminedichloroplatinum(II) (cis-DDP) and cis,trans,cis-ammine(cyclohexylamine)-dibutyratodichloroplatinu m(IV) (ACDDP) are anticancer drugs that bind to DNA, forming replication blocking adducts. ACDDP, probably manifests its cytotoxicity through the metabolite cis-ammine(cyclohexylamine)dichloroplatinum(II) (ACDP). The biological effects of ACDP and… CONTINUE READING