Effects of DCA on Cell Cycle Proteins in Colonocytes

  title={Effects of DCA on Cell Cycle Proteins in Colonocytes},
  author={Yun-Hyung Ha and Dong-Guk Park},
  booktitle={Journal of the Korean Society of Coloproctology},
PURPOSE Evidence that indicates bile acid is a promoter of colon cancer exists. Deoxycholic acid (DCA) modifies apoptosis or proliferation by affecting intracellular signaling and gene expression. However, because previous studies have been based on studies on colon cancer cell lines, the effect of DCA on normal colonocytes is unknown. METHODS Normal colonocytes and Caco-2 and HCT116 cells were treated with 20 µM and 250 µM of DCA, and the effect of different concentrations of DCA was… CONTINUE READING