Effects of DA-6034 on aqueous tear fluid secretion and conjunctival goblet cell proliferation.

  title={Effects of DA-6034 on aqueous tear fluid secretion and conjunctival goblet cell proliferation.},
  author={Seul Min Choi and Yeong-Geon Lee and Mi Jung Seo and Kyung Koo Kang and Byoung Ok Ahn and Moohi Yoo},
  journal={Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics},
  volume={25 3},
  • S. Choi, Yeong-Geon Lee, M. Yoo
  • Published 20 May 2009
  • Medicine, Biology
  • Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
PURPOSE This study was conducted to evaluate the effect of DA-6034, a potent secretagogue, on aqueous tear fluid secretion and its quality in normal rabbit. We also evaluated, in animal models of experimentally induced dry eye disease, its effectiveness over time to stimulate aqueous tear production by ocular ferning test and goblet cell proliferation. METHODS Aqueous tear production, total protein levels, and glycoprotein levels in normal rabbits were evaluated after topical application of… 

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