Effects of D1 and D2 dopamine receptor antagonists on cocaine-induced self-stimulation and locomotor activity in rats.

@article{Kita1999EffectsOD,
  title={Effects of D1 and D2 dopamine receptor antagonists on cocaine-induced self-stimulation and locomotor activity in rats.},
  author={Keiji Kita and Toshihiro Shiratani and Kaoru Takenouchi and Hiroshi Fukuzako and Morikuni Takigawa},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  year={1999},
  volume={9 1-2},
  pages={1-7}
}
To clarify the involvement of D1 and D2 dopamine systems in intracranial self-stimulation (ICSS) and locomotor activity in rats, we studied the acute effects of cocaine and the interaction between cocaine and dopamine antagonists with respect to these behaviors. Although cocaine (5.0, 10.0, or 20.0 mg/kg) dose-dependently increased locomotor activity, it augmented the rate of ICSS only at 5.0 mg/kg. The failure of high doses of cocaine to augment purpose-oriented behavior such as ICSS may… CONTINUE READING

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