Effects of D-series resolvins on behavioral and neurochemical changes in a fibromyalgia-like model in mice

@article{Klein2014EffectsOD,
  title={Effects of D-series resolvins on behavioral and neurochemical changes in a fibromyalgia-like model in mice},
  author={Caroline Peres Klein and Nathalia D. M. Sperotto and Izaque S. Maciel and Carlos Leite and Maria M Campos},
  journal={Neuropharmacology},
  year={2014},
  volume={86},
  pages={57-66}
}
This study investigated whether the spinal or systemic treatment with the lipid resolution mediators resolvin D1 (RvD1), aspirin-triggered resolvin D1 (AT-RvD1) and resolvin D2 (RvD2) might interfere with behavioral and neurochemical changes in the mouse fibromyalgia-like model induced by reserpine. Acute administration of AT-RvD1 and RvD2 produced a significant inhibition of mechanical allodynia and thermal sensitization in reserpine-treated mice, whereas RvD1 was devoid of effects. A similar… CONTINUE READING
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The effects of Pha1b, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model

  • A. H. de Souza, A. M. da Costa Lopes, +6 authors M. V. Gomez
  • Toxicon 81C,
  • 2014
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