Effects of D-glucose upon D-fuctose metabolism in rat hepatocytes: A 13C NMR study

@article{Malaisse2002EffectsOD,
  title={Effects of D-glucose upon D-fuctose metabolism in rat hepatocytes: A 13C NMR study},
  author={Willy Jean Malaisse and L. Ladrie{\`e}re and Ingrid Verbruggen and Rudolph Willem},
  journal={Molecular and Cellular Biochemistry},
  year={2002},
  volume={241},
  pages={103-106}
}
Isolated hepatocytes from fed rats were exposed for 120 min to D-glucose (10 mM) and either D-[1-13C]fructose, D-[2-13C]fructose or D-[6-13C]fructose (also 10 mM) in the presence of D2O. The identification and quantification of 13C-enriched D-fructose and its metabolites (D-glucose, L-lactate, L-alanine) in the incubation medium and the measurement of their deuterated isotopomers indicated, by comparison with a prior study conducted in the absence of exogenous D-glucose, that the major effects… CONTINUE READING
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