Effects of Creatine Supplementation on Renal Function: A Systematic Review and Meta-Analysis.

@article{deSouzaESilva2019EffectsOC,
  title={Effects of Creatine Supplementation on Renal Function: A Systematic Review and Meta-Analysis.},
  author={Alexandre de Souza E Silva and Adriana Pertille and Carolina Gabriela Reis Barbosa and Jasiele Aparecida de Oliveira Silva and Diego Vilela de Jesus and Anna Gabriela Silva Vilela Ribeiro and Ronaldo J{\'u}lio Baganha and J J de Oliveira},
  journal={Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation},
  year={2019}
}
Creatine supplements are intended to improve performance, but there are indications that it can overwhelm liver and kidney functions, reduce the quality of life, and increase mortality. Therefore, this is the first systematic review and meta-analysis study that aimed to investigate creatine supplements and their possible renal function side effects. After evaluating 290 non-duplicated studies, 15 were included in the qualitative analysis and 6 in the quantitative analysis. The results of the… 
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TLDR
Creatine supplementation minimally impacts creatinine concentrations and renal function in young healthy adults and the increase in creatinin concentrations after long periods of creatine supplementation is extremely limited and unlikely to affect estimates of Creatine clearance and subsequent dosage adjustments.
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Creatine supplementation can effectively lower plasma Hcy concentrations in an animal model of uremia and should be further investigated as a potential treatment for hyperhomocysteinemia in patients with ESRD.
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TLDR
The decrease in cystatin C indicates that high-dose creatine supplementation over 3 months does not provoke any renal dysfunction in healthy males undergoing aerobic training, and the results suggest that moderate aerobic training per se may improve renal function.
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TLDR
Doctors should be aware that the safety of long-term creatine supplementation, in regard to the effects on the kidneys, cannot be guaranteed and more information is needed on possible changes in blood pressure, protein/albumin excretion, and glomerular filtration in athletes who are habitual users of this compound.
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TLDR
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TLDR
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TLDR
Although creatine supplementation appears to have no detrimental effects on kidney function of individuals without underlying kidney diseases, it seems more advisable to suggest that creatine supplementation not to be used by sportsmen or women with pre-existing kidney disease or those with a potential risk for kidney dysfunction.
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