Effects of Cox-2 Inhibitors and Translocator Protein Drug Ligands on Progesterone Production by Mouse Leydig Tumor Cells

Abstract

Cyclooxygenase 2 (COX-2) inhibitors and translocator protein 18 kDa (TSPO) drug ligands have been shown to have stimulatory effects on steroid production. Given that their mechanisms of action differ, we hypothesized that a combination treatment of both TSPO drug ligands and COX-2 inhibitors might have additive or synergistic effects on steroid production… (More)

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