Corpus ID: 20911900

Effects of Cordyceps militaris extract on angiogenesis and tumor growth.

@article{Yoo2004EffectsOC,
  title={Effects of Cordyceps militaris extract on angiogenesis and tumor growth.},
  author={Hwa-Seung Yoo and Jang-woo Shin and Jung-Hyo Cho and Chang-Gue Son and Yeon-weol Lee and Sang-yong Park and Chong-kwan Cho},
  journal={Acta pharmacologica Sinica},
  year={2004},
  volume={25 5},
  pages={
          657-65
        }
}
AIM To evaluate the effects of Cordyceps militaris extract (CME) on angiogenesis and tumor growth. METHODS Human umbilical vein endothelial cells (HUVEC), HT1080, and B16-F10 cells were used. DNA fragment, angiogenic related gene expressions (MMPs, bFGF, VEGF, etc), capillary tube formation, wound healing in vitro, tumor growth in vivo were measured. RESULTS CME inhibited growth of HUVECs and HT1080 (P<0.01). CME 100 and 200 mg/L reduced MMP-2 gene expression in HT1080 cells by 6.0 % and 22… Expand
The antiangiogenic activities of ethanolic crude extracts of four Salvia species
TLDR
Findings of the direct and indirect angiogenic investigations nominated S. triloba as a highly potent antiangiogenic plant that may have chemotherapeutic and/or chemoprevention potentials. Expand
In vitro evaluation of Cordyceps militaris as a potential radioprotective agent.
TLDR
It is suggested that the free radical scavenging activity of CM-AE contributes towards its DNA radioprotective effects and that the protective effects ofCM-AE are much more potent to those of cordycepin. Expand
Cordyceps militaris induces tumor cell death via the caspase-dependent mitochondrial pathway in HepG2 and MCF-7 cells
TLDR
The data obtained in the present study suggested that the cytotoxic effects of CM aqueous extract on HCC and breast cancer are associated with the caspase-dependent mitochondrial pathway. Expand
Anti-tumor activity of the fermentation broth of Cordyceps militaris cultured in the medium of Radix astragali
TLDR
The fermentation broth had low cytotoxicity against primary rat hepatocytes, and did not impose serious side effect on the vital organs of the mice as compared to the chemotherapeutic drug 5-FU. Expand
Induction of apoptosis by Cordyceps militaris through activation of caspase-3 in leukemia HL-60 cells.
TLDR
Results indicate that the hot water extract of Cordyceps militaris fruiting bodies inhibited cancer cell proliferation by inducing cell apoptosis through the activation of caspase-3, and that the Cordyces militaris extract may therefore have therapeutic potential against human leukemia. Expand
Cordycepin modulates inflammatory and catabolic gene expression in interleukin-1beta-induced human chondrocytes from advanced-stage osteoarthritis: an in vitro study.
TLDR
The results suggest that cordycepin may possess chondroprotective effect by preventing cartilage denegation and interfering inflammatory response in the pathogenesis of OA. Expand
Immunostimulating activity of the polysaccharides isolated from Cordyceps militaris.
TLDR
Macrophages activation by CM seemed to occur via activation of NF-κB and all three MAPKs pathways through dectin-1 and TLR2 macrophage receptors, suggesting that CM may potentially regulate the immune response. Expand
Water extract of Cordyceps militaris enhances maturation of murine bone marrow-derived dendritic cells in vitro.
TLDR
Water extract of Cordyceps militaris induces the phenotypic and functional maturation of dendritic cells (DC) and is shown to promote the cytotoxicity of specific-cytotoxic T lymphocytes induced by DC which were pulsed with P815 tumor-lysate during the stage of antigen presentation. Expand
Cordycepin prevented IL-β-induced expression of inflammatory mediators in human osteoarthritis chondrocytes
TLDR
Pretreatment with cordycepin significantly inhibited the production of PGE2 and NO induced by IL-1β and significantly decreased the IL- 1β-stimulated gene expression and production of MMP-13, IL-6, iNOS and COX-2 in OA chondrocytes. Expand
Cordyceps militaris (L.) Link Fruiting Body Reduces the Growth of a Non-Small Cell Lung Cancer Cell Line by Increasing Cellular Levels of p53 and p21
TLDR
This work suggests that the methanolic extract of C. militaris affected NCI-H460 cellular viability through a mechanism involving DNA damage and p53 activation, which supports the potential of this extract as a source of bioactive compounds, which may be used in anticancer strategies. Expand
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