Corpus ID: 20911900

Effects of Cordyceps militaris extract on angiogenesis and tumor growth.

  title={Effects of Cordyceps militaris extract on angiogenesis and tumor growth.},
  author={H. Yoo and Jang-woo Shin and Jung-Hyo Cho and Chang-gue Son and Yeon-weol Lee and S. Park and Chong-kwan Cho},
  journal={Acta pharmacologica Sinica},
  volume={25 5},
  • H. Yoo, Jang-woo Shin, +4 authors Chong-kwan Cho
  • Published 2004
  • Medicine, Biology
  • Acta pharmacologica Sinica
  • AIM To evaluate the effects of Cordyceps militaris extract (CME) on angiogenesis and tumor growth. METHODS Human umbilical vein endothelial cells (HUVEC), HT1080, and B16-F10 cells were used. DNA fragment, angiogenic related gene expressions (MMPs, bFGF, VEGF, etc), capillary tube formation, wound healing in vitro, tumor growth in vivo were measured. RESULTS CME inhibited growth of HUVECs and HT1080 (P<0.01). CME 100 and 200 mg/L reduced MMP-2 gene expression in HT1080 cells by 6.0 % and 22… CONTINUE READING
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