Effects of Copper and Cross-Linking on the Extracellular Matrix of Tissue-Engineered Arteries.

  title={Effects of Copper and Cross-Linking on the Extracellular Matrix of Tissue-Engineered Arteries.},
  author={Shannon L. M. Dahl and Robert B. Rucker and Laura E. Niklason},
  journal={Cell transplantation},
  volume={14 6},
In many cases, the mechanical strengths of tissue-engineered arteries do not match the mechanical strengths of native arteries. Ultimate arterial strength is primarily dictated by collagen in the extracellular matrix, but collagen in engineered arteries is not as dense, as organized, or as mature as collagen in native arteries. One step in the maturation process of collagen is the formation of hydroxylysyl pyridinoline (HP) cross-links between and within collagen molecules. HP cross-link… CONTINUE READING
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