Effects of Continuous‐Wave (670‐nm) Red Light on Wound Healing

@article{Erdle2008EffectsOC,
  title={Effects of Continuous‐Wave (670‐nm) Red Light on Wound Healing},
  author={Brandon Erdle and Sabine M. Brouxhon and Martin C. Kaplan and Joanne Vanbuskirk and Alice P. Pentland},
  journal={Dermatologic Surgery},
  year={2008},
  volume={34},
  pages={320–325}
}
BACKGROUND Recent work suggests that injuries can heal faster if treated by lasers emitting 670-nm red light. LED lights emitting 670-nm light are now available. This suggests that inexpensive and easy-to-use 670-nm LED lights might help accelerate cutaneous wound healing. OBJECTIVE The objective was to evaluate the effect of 670-nm LED light on wound healing in SKH-1 hairless mice. METHODS To study 670-nm light effects on incisional injury, animals were left unexposed or exposed to equal doses… 
Effect of 660 nm Light-Emitting Diode on the Wound Healing in Fibroblast-Like Cell Lines
TLDR
Exposure to the 660 nm red LED resulted in an increase in cell proliferation and migration compared to the control, indicating its potential use as a phototherapeutic agent.
J 630 nm Light Emitting Diode Irradiation Improves Dermal Wound Healing in Rats
TLDR
630 nm LED with 3.67 mW/cm, 6.60 J/cm accelerate collagen deposition by stimulating fibroblasts, and enhance wound contraction by differentiating myofibroBLasts in the dermis, and accelerate keratinocyte proliferation by facilitating DNA synthesis in the epidermis.
Photo-biomodulatory response of low-power laser irradiation on burn tissue repair in mice
TLDR
It is demonstrated that a single exposure of 3-J/cm2 fluence at 830-nm enhanced burn wound healing progression in mice, which is equivalent to 5 % povidone iodine treatment (reference standard), applied on a daily basis till complete healing.
Effect of visible and infrared polarized light on the healing process of full-thickness skin wounds: an experimental study.
TLDR
Evaluating the effect of visible and infrared polarized light of a specific range of wavelength on the secondary healing of full-thickness skin wounds in rats found this specific fraction of polarized light seems to have beneficial effects on wound healing, leading to faster epithelialization and qualitatively better wound healing.
Protective effect of light emitting diode phototherapy on fluorescent light induced retinal damage in Wistar strain albino rats
TLDR
The aim of this study has been to elucidate the protective effects of 670 nm LED light on retinal damage induced by chronic fluorescent light in Wistar rats.
Effect of incoherent LED radiation on third-degree burning wounds in rats
TLDR
The results indicated that the treatment with a LED system was clearly effective in reducing the number of inflammatory cells and improving the healing process in an experimental model of third-degree burnings.
HeaLED: Assessment of skin healing under light-emitting diode (LED) exposure-A randomized controlled study versus placebo.
TLDR
Photobiomodulation failed to improve healing after laser ablation compared to placebo, and no significant differences in the variation of the parameter a* or any of the other studied parameters were found for the different LEDs compared to the placebo area.
Therapeutic application of light emitting diode: Photo-oncomic approach.
A preliminary study of the safety of red light phototherapy of tissues harboring cancer.
TLDR
This experiment suggests that LLLT at these parameters may be safe even when malignant lesions are present, and further studies on the effects of photoirradiation on neoplasms are warranted.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 27 REFERENCES
Effect of NASA light-emitting diode irradiation on wound healing.
TLDR
The use of NASA LED for light therapy alone, and in conjunction with hyperbaric oxygen, will greatly enhance the natural wound healing process, and more quickly return the patient to a preinjury/illness level of activity.
Effect of low-power density laser radiation on healing of open skin wounds in rats.
TLDR
There may be a wavelength-selective influence of coherent light on the metabolic and proliferation processes in wound healing, with the associated problem of the possible carcinogenic effects of laser radiation.
Effect of helium‐neon and infrared laser irradiation on wound healing in rabbits
TLDR
Laser irradiation at 632.8 nm and 904 nm alone or in combination increased tensile strength during wound healing and may have released tissue factors into the systemic circulation that increased Tensile strength on the opposite side as well.
Laser photostimulation accelerates wound healing in diabetic rats
  • G. Reddy, L. Stehno-Bittel, C. Enwemeka
  • Biology, Medicine
    Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
  • 2001
TLDR
The biomechanical and biochemical results collectively suggest that laser photostimulation promotes the tissue repair process by accelerating collagen production and promoting overall connective tissue stability in healing wounds of diabetic rats.
Laser biostimulation of healing wounds: specific effects and mechanisms of action.
  • C. Enwemeka
  • Medicine, Biology
    The Journal of orthopaedic and sports physical therapy
  • 1988
TLDR
The literature reviewed suggests that biostimulation with lasers accelerates the inflammatory phase of wound healing by altering the levels of various prostaglandins, increases ATP synthesis by enhancing electron transfer in the inner membrane of mitochondria, and quickens protein (collagen) synthesis by quickening DNA and RNA synthesis.
Photobiological Principles of Therapeutic Applications of Laser Radiation
TLDR
Besides LIL, light-emitting diodes are used in phototherapy (photobiostimulation) whose action depends on the radiation wavelength, dose, and distribution of light intensity in time but, according to all available data, does not depend on the coherence of radiation.
Effect of laser rays on wound healing.
Donors of NO and pulsed radiation at lambda = 820 nm exert effects on cell attachment to extracellular matrices.
TLDR
It was found that in an irradiated cell suspension, the cell-glass adhesion increases in a dose-dependent manner (a bell-shaped curve with a maximum at 60 J/m(2), and it is suggested that a modulation of the activity of respiratory chain is involved in radiation-induced increase of cell attachment.
Therapeutic photobiomodulation for methanol-induced retinal toxicity
  • J. Eells, M. Henry, +5 authors H. Whelan
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2003
TLDR
These findings provide a link between the actions of monochromatic red to near-IR light on mitochondrial oxidative metabolism in vitro and retinoprotection in vivo and suggest that photobiomodulation may enhance recovery from retinal injury and other ocular diseases in which mitochondrial dysfunction is postulated to play a role.
...
1
2
3
...