Effects of Concomitant Fluvoxamine on the Plasma Concentration of Etizolam in Japanese Psychiatric Patients: Wide Interindividual Variation in the Drug Interaction

@article{Suzuki2004EffectsOC,
  title={Effects of Concomitant Fluvoxamine on the Plasma Concentration of Etizolam in Japanese Psychiatric Patients: Wide Interindividual Variation in the Drug Interaction},
  author={Y. Suzuki and Y. Kawashima and T. Shioiri and T. Someya},
  journal={Therapeutic Drug Monitoring},
  year={2004},
  volume={26},
  pages={638-642}
}
  • Y. Suzuki, Y. Kawashima, +1 author T. Someya
  • Published 2004
  • Medicine
  • Therapeutic Drug Monitoring
  • Administration of fluvoxamine with concomitant benzodiazepines is common in clinical situations. This study investigated the effects of the coadministration of fluvoxamine on plasma concentrations of etizolam and evaluated the effects of various fluvoxamine doses on drug interactions with etizolam. Subjects were 18 Japanese outpatients concomitantly treated with fluvoxamine before or after monotherapy with etizolam. Plasma concentrations of etizolam were measured using a column-switching high… CONTINUE READING
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    References

    SHOWING 1-10 OF 13 REFERENCES
    Effects of concomitant fluvoxamine on the metabolism of alprazolam in Japanese psychiatric patients: interaction with CYP2C19 mutated alleles
    • 10
    A pharmacokinetic and pharmacodynamic evaluation of the combined administration of alprazolam and fluvoxamine
    • 114
    Inhibition of diazepam metabolism by fluvoxamine: A pharmacokinetic study in normal volunteers
    • 92
    Single and multiple dose pharmacokinetics of etizolam in healthy subjects
    • 40
    • Highly Influential
    Importance of the Cytochrome P450 2D6 Genotype for the Drug Metabolic Interaction Between Chlorpromazine and Haloperidol
    • 15
    Dose-response evaluation of the interaction between sertraline and alprazolam in vivo.
    • 21
    • PDF
    Drug interactions with newer antidepressants: role of human cytochromes P450.
    • 145
    • Highly Influential
    Drug interactions--friend or foe?
    • 37