• DOI:10.1271/bbb.100156
• Corpus ID: 24776274

Effects of Compressed Hydrocarbon Gases on the Growth Activity of Saccharomyces cerevisiae

@article{Kawachi2010EffectsOC,
  title={Effects of Compressed Hydrocarbon Gases on the Growth Activity of Saccharomyces cerevisiae},
  author={Satoshi Kawachi and Yoshio Hara and Toshiaki Arao and Yoshihisa Suzuki and Katsuhiro Tamura},
  journal={Bioscience, Biotechnology, and Biochemistry},
  year={2010},
  volume={74},
  pages={1991 - 1996}
}

• S. Kawachi, Y. Hara, +2 authors K. Tamura
• Published 23 October 2010
• Chemistry, Biology
• Bioscience, Biotechnology, and Biochemistry

The inhibitory action of compressed hydrocarbon gases on the growth of the yeast Saccharomyces cerevisiae was investigated quantitatively by microcalorimetry. Both the 50% inhibitory pressure (IP50) and the minimum inhibitory pressure (MIP), which are regarded as indices of the toxicity of hydrocarbon gases, were determined from growth thermograms. Based on these values, the inhibitory potency of the hydrocarbon gases increased in the order methane << ethane < propane < i-butane < n-butane. The toxicity of these hydrocarbon gases correlated to their hydrophobicity, suggesting that hydrocarbon gases interact with some hydrophobic regions of the cell membrane. In support of this, we found that UV absorbing materials at 260 nm were released from yeast cells exposed to compressed hydrocarbon gases. Additionally, scanning electron microscopy indicated that morphological changes occurred in these cells.