Effects of Combination of Amlodipine and Valsartan on in Vivo Pharmacokinetics of Valsartan in Rats

@inproceedings{Jinhon2014EffectsOC,
  title={Effects of Combination of Amlodipine and Valsartan on in Vivo Pharmacokinetics of Valsartan in Rats},
  author={Xu Jin-hon},
  year={2014}
}
OBJECTIVE To study the phamackinetics of amlodipine and valsartan for valsartan in rats,and to investigate the antihypertensive effect of combined treatment. METHODS Twelve male SD rats were divided into two groups. The valsartan( 16 mg·kg- 1) and Exforge( containing valsartan 16 mg·kg- 1,amlodipine 1 mg·kg- 1) were given by using stomach tube respectively to rats. Blood samples were taken for detecting plasma concentration before dosing and at 0,0. 33,0. 67,1,2,4,8,12 and 24 h after a single… CONTINUE READING