Effects of Codon Usage on Gene Expression: Empirical Studies on Drosophila

@inproceedings{Powell2015EffectsOC,
  title={Effects of Codon Usage on Gene Expression: Empirical Studies on Drosophila},
  author={Jeffrey R. Powell and Kirstin B. Dion},
  booktitle={Journal of Molecular Evolution},
  year={2015}
}
For most amino acids, more than one codon can be used. Many hypotheses have been put forward to account for patterns of uneven use of synonymous codons (codon usage bias) that most often have been indirectly tested primarily by analyses of patterns. Direct experimental tests of effects of synonymous codon usage are available for unicellular organisms, however empirical data addressing this problem in multicellular eukaryotes are sparse. We have developed a flexible transfecting plasmid that… CONTINUE READING
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