Effects of Cocaine on Cortisol Secretion in Humans

@article{Heesch1995EffectsOC,
  title={Effects of Cocaine on Cortisol Secretion in Humans},
  author={Christian M. Heesch and Brian H. Negus and J H Keffer and Richard W. Snyder and R C Risser and Eric J. Eichhorn},
  journal={The American Journal of The Medical Sciences},
  year={1995},
  volume={310},
  pages={61–64}
}
The effects of acute cocaine administration on the pituitary adrenal axis in humans without a history of drug abuse are unknown. The authors studied 12 male volunteers twice in a double-blinded, placebo-controlled, randomized fashion. After intranasal administration of 2 mg/kg cocaine, cortisol levels were significantly higher than after placebo administration. The authors concluded that acute administration of cocaine to humans increases cortisol secretion. 
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