Effects of Cigarette Smoke, Cessation, and Switching to Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism in C57BL/6 and Apoe−/− Mice—An Integrative Systems Toxicology Analysis

@inproceedings{Titz2016EffectsOC,
  title={Effects of Cigarette Smoke, Cessation, and Switching to Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism in C57BL/6 and Apoe−/− Mice—An Integrative Systems Toxicology Analysis},
  author={Bjoern Titz and St{\'e}phanie Bou{\'e} and Blaine W Phillips and Marja Talikka and Terhi Vihervaara and Thomas Schneider and Catherine Nury and Ashraf Elamin and Emmanuel Guedj and Michael John Peck and Walter K. Schlage and Maciej Cabanski and Patrice Leroy and Gr{\'e}gory Vuillaume and Florian Martin and Nikolai V. Ivanov and Emilija Veljkovic and Kim Ekroos and Reijo Laaksonen and Patrick M Vanscheeuwijck and Manuel C. Peitsch and Julia Hoeng},
  booktitle={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2016}
}
The impact of cigarette smoke (CS), a major cause of lung diseases, on the composition and metabolism of lung lipids is incompletely understood. Here, we integrated quantitative lipidomics and proteomics to investigate exposure effects on lung lipid metabolism in a C57BL/6 and an Apolipoprotein E-deficient (Apoe(-/-)) mouse study. In these studies, mice were exposed to high concentrations of 3R4F reference CS, aerosol from potential modified risk tobacco products (MRTPs) or filtered air (Sham… CONTINUE READING