Effects of Chronic Cortisol Administration on Global Expression of GR and the Liver Transcriptome in Sparus aurata

@article{Teles2012EffectsOC,
  title={Effects of Chronic Cortisol Administration on Global Expression of GR and the Liver Transcriptome in Sparus aurata},
  author={Mariana Teles and Sebasti{\'a}n Bolta{\~n}a and Felipe E. Reyes-L{\'o}pez and Maria Ana Santos and Simon Mackenzie and L. Tort},
  journal={Marine Biotechnology},
  year={2012},
  volume={15},
  pages={104-114}
}
The present work was designed to assess the effects of artificially increased high plasma cortisol levels induced by slow-release cortisol implants on the mRNA abundance of the glucocorticoid receptor (GR) in different organs of Sparus aurata (Gilthead sea bream), as well as to evaluate global transcriptional changes in the liver, using the Aquagenomics S. aurata oligo-nucleotide microarray technology. For that purpose, groups of fish were intraperitoneally injected with implants containing two… CONTINUE READING
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