Effects of Central Nervous System Drugs on Recovery After Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

@article{Yeo2017EffectsOC,
  title={Effects of Central Nervous System Drugs on Recovery After Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials},
  author={See-Hwee Yeo and Zheng-Jie Ian Lim and Jia Mao and Wai-Ping Yau},
  journal={Clinical Drug Investigation},
  year={2017},
  volume={37},
  pages={901-928}
}
Background and ObjectivePilot trials have suggested that pharmacotherapy may aid stroke recovery. The aim of this study was to systematically review the effects of antidepressants, anti-Alzheimer drugs, anti-Parkinson drugs, central nervous system (CNS) stimulants and piracetam on gross motor function, cognition, disability, dependency and quality of life (QOL) after stroke.MethodsPubMed, EMBASE and the Cochrane Central Register of Controlled Trials databases were searched, and 44 randomized… Expand
Efficacy and tolerability of selective serotonin reuptake inhibitors on promoting motor recovery after stroke:meta-analysis of randomized controlled trials
  • Dongyun Su, Yuqing Zhang, +6 authors Haiyan Luo
  • Medicine
  • Expert review of neurotherapeutics
  • 2021
TLDR
SSRIs are effective and well-tolerated to promote motor recovery after stroke, but may increase the risk of seizures and gastrointestinal adverse effects. Expand
Use of Selective Serotonin Reuptake Inhibitors and Outcomes in Stroke Rehabilitation: A Prospective Observational Pilot Cohort Study
TLDR
SSRI therapy did not improve disability and QOL in multi-ethnic Asian patients with first-ever stroke undergoing rehabilitation, and no significant association between SSRI therapy and any of the investigated outcomes was found after adjustment for confounders. Expand
Fluoxetine for motor recovery after acute intracerebral hemorrhage, the FMRICH trial
TLDR
In addition to standard treatment, early prescription of fluoxetine was safe and helped to increase motor recovery 90 days after ICH, adding to the evidence regarding its beneficial effect upon stroke related disability. Expand
Potential Role of Selective Serotonin Reuptake Inhibitors in Improving Functional Outcome after Stroke
TLDR
The evidence for SSRIs as potential enhancers of stroke recovery is reviewed and the potential mechanisms behind the effects reported and the implications for the management of patients post-stoke are discussed, including potential adverse events and drug–drug interactions. Expand
Pharmacological Interventions to Enhance Stroke Recovery
TLDR
Animal and human evidence support the beneficial effect of selective serotonin reuptake inhibitors (SSRIs) on motor recovery post stroke and in cognitive recovery, but there is not a unified recommendation for using SSRIs, and cholinergic or dopaminergic agents. Expand
Serotonin Selective Reuptake Inhibitors (SSRIs) and Stroke
TLDR
Global coherence is appearing, showing that SSRIs improve stroke recovery in non-depressed patients when given for 3 months after the stroke, with highly favourable safety conditions and a favourable benefit/risk ratio. Expand
Anticholinergic and Sedative Drug Burden and Functional Recovery after Cerebrovascular Accident: A Retrospective Descriptive Study
TLDR
The study of Japanese patients who were transferred from acute stroke care hospitals to a rehabilitation facility identified the drug burden of anticholinergics and sedatives as an independent factor associated with the time to recovery of activities of daily living and postural balance. Expand
Pharmacological management of post-stroke depression: an update of the evidence and clinical guidance
TLDR
Although there are still gaps in knowledge of PSD, the seriousness should not be neglected, and pharmacological treatment should be recommended when relevant, and close follow-up and dose adjustments as well as add-on possibilities are important aspects of treatment. Expand
Post-stroke Depression Increases Disability More Than 15% in Ischemic Stroke Survivors: A Case-Control Study
TLDR
The results confirm the unfavorable influence of PSD on functional outcome, despite pharmacological treatment, despite treatment with serotoninergic antidepressants. Expand
Adjunctive cytoprotective therapies in acute ischemic stroke: a systematic review
TLDR
An overview of compounds tested in clinical AIS trials is provided and insight is given into which of these drugs warrant a re-evaluation as an add-on therapy for AIS in the era of EVT. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 142 REFERENCES
Selective Serotonin Reuptake Inhibitors for Stroke Recovery: A Systematic Review and Meta-analysis
TLDR
A meta-analysis of all (published and unpublished) randomized controlled trials of SSRI compared with control, given within the first year of stroke, to determine the effect on dependency, disability, and other important clinical outcomes. Expand
Selective serotonin reuptake inhibitors (SSRIs) for stroke recovery
TLDR
WhetherSSRIs improve recovery after stroke, and whether treatment with SSRIs was associated with adverse effects, was determined, and there were statistically significant benefits of SSRI on both of the primary outcomes. Expand
Fluoxetine in early poststroke depression: a double-blind placebo-controlled study.
TLDR
FLX is an efficacious and well-tolerated treatment for early PSD and further research is needed to evaluate the efficacy and safety of long-term treatment in this population. Expand
Prophylactic Effects of Duloxetine on Post-Stroke Depression Symptoms: An Open Single-Blind Trial
TLDR
The prophylactic use of duloxetine not only decreased the incidence of PSD, but also promoted rehabilitation, cognitive function and quality of life. Expand
Fluoxetine for poststroke depression: A randomized placebo controlled clinical trial
TLDR
The aim was to observe the effect of fluoxetine on preventing against PSD and recovery of neurologic function, and analyze the relationship of fluxetine and the 5-HT level. Expand
Safety of selective serotonin reuptake inhibitor treatment in recovering stroke patients
TLDR
Evidence suggests that SSRIs may enhance stroke recovery, and several ongoing large randomized trials are awaited beforeSSRIs can be recommended as a routine pharmacotherapy in stroke recovery. Expand
Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial
TLDR
In patients with ischaemic stroke and moderate to severe motor deficit, the early prescription of fluoxetine with physiotherapy enhanced motor recovery after 3 months. Expand
An Open-Label Pilot Study of Acetylcholinesterase Inhibitors to Promote Functional Recovery in Elderly Cognitively Impaired Stroke Patients
TLDR
In this open-label study, participants receiving donepezil had better functional recovery than participants receiving galantamine or the historical comparators, and this improvement may reflect efficacy at the starting dose fordonepezil but not galantamines. Expand
Methylphenidate in early poststroke recovery: a double-blind, placebo-controlled study.
TLDR
Methylphenidate appears to be a safe and effective intervention in early poststroke rehabilitation that may expedite recovery. Expand
Effect of Piracetam on Recovery and Rehabilitation After Stroke: A Double‐Blind, Placebo‐Controlled Study
TLDR
An improvement in aphasia in patients undergoing rehabilitation after a stroke after 12 weeks' treatment with piracetam is shown, but an effect on tests of activities of daily living is unable to be demonstrated and the effect on perceptual deficit is not confirmed. Expand
...
1
2
3
4
5
...