Effects of Celecoxib on Acid-Challenged Gastric Mucosa of Rats: Comparison with Metamizol and Piroxicam

@article{Berenguer2004EffectsOC,
  title={Effects of Celecoxib on Acid-Challenged Gastric Mucosa of Rats: Comparison with Metamizol and Piroxicam},
  author={Bettina Berenguer and Catalino Alarc{\'o}n De la Lastra and Virginia Motilva and Carmen La Casa and Juan Manuel Herrer{\'i}as and David Patricio Viscarra del Pozo and Mar{\'i}a Jos{\'e} Martin Calero},
  journal={Digestive Diseases and Sciences},
  year={2004},
  volume={49},
  pages={937-947}
}
Selective COX-2 inhibitors have been shown to produce fewer gastrointestinal adverse reactionsthan classical NSAIDs. Nevertheless, these new agents may worsen and delay the healing of ex-perimentallyinduced gastric ulcers in animals. In this study, we compared the effects of a selectiveCOX-2 inhibitor (celecoxib), a preferential COX-1 inhibitor (piroxicam), and a nonnarcotic anal-gesic(metamizol) on normal gastric mucosa of rats and, on the other hand, in a setting of preexistingacute gastric… CONTINUE READING
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