Effects of Carvacrol on Survival, Mesenteric Blood Flow, Aortic Function and Multiple Organ Injury in a Murine Model of Polymicrobial Sepsis

@article{Ozer2017EffectsOC,
  title={Effects of Carvacrol on Survival, Mesenteric Blood Flow, Aortic Function and Multiple Organ Injury in a Murine Model of Polymicrobial Sepsis},
  author={Erdem Kamil Ozer and Mustafa Tugrul Goktaş and Asuman Toker and Hulagu Bariskaner and Ceyhan Uğurluoğlu and Alper B Iskit},
  journal={Inflammation},
  year={2017},
  volume={40},
  pages={1654-1663}
}
Carvacrol (CRV) has strong cytoprotective, antioxidant, and anti-inflammatory properties. We aimed to demonstrate the possible protective effects of CRV on survival, mesenteric artery blood flow (MBF), vascular reactivity, and oxidative and inflammatory injuries in a murine model of polymicrobial sepsis induced by cecal ligation and puncture (CLP). Wistar rats were allocated into the following four groups: Sham, CLP, Sham + CRV, and CLP + CRV. The animals were orally administered with CRV (80… CONTINUE READING
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