Effects of CapZ, an actin capping protein of muscle, on the polymerization of actin.

@article{Caldwell1989EffectsOC,
  title={Effects of CapZ, an actin capping protein of muscle, on the polymerization of actin.},
  author={James E. Caldwell and Stephan Heiss and Valerie Mermall and John A. Cooper},
  journal={Biochemistry},
  year={1989},
  volume={28 21},
  pages={8506-14}
}
We have studied the interaction of CapZ, a barbed-end actin capping protein from the Z line of skeletal muscle, with actin. CapZ blocks actin polymerization and depolymerization (i.e., it "caps") at the barbed end with a Kd of approximately 0.5-1 nM or less, measured by three different assays. CapZ inhibits the polymerization of ATP-actin onto filament ends with ATP subunits slightly less than onto ends with ADP subunits, and onto ends with ADP-BeF3- subunits about as much as ends with ADP… CONTINUE READING
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