Effects of Cannabinoid Receptor Agonists on Rat Gastric Acid Secretion: Discrepancy Between In Vitro and In Vivo Data

@article{Coruzzi2006EffectsOC,
  title={Effects of Cannabinoid Receptor Agonists on Rat Gastric Acid Secretion: Discrepancy Between In Vitro and In Vivo Data},
  author={Gabriella Coruzzi and Maristella Adami and Elena Guaita and Alessandro Menozzi and Simone Bertini and Elena Giovannini and MD Giulio Soldani},
  journal={Digestive Diseases and Sciences},
  year={2006},
  volume={51},
  pages={310-317}
}
The effects of the cannabinoid (CB)-receptor agonists WIN55,212-2 and HU-210 and the selective CB1-receptor antagonist SR141716A were tested on in vitro and in vivo acid secretion assays from the rat. In the isolated gastric fundus from immature rats, WIN55,212-2 (0.001–30 μ M), HU-210 (0.001–10 μ M), or SR141716A (0.1–10 μ M) did not change the basal acid output or acid responses to histamine, pentagastrin, or electrical field stimulation. HU-210 (0.3 μ mol/kg, intravenously) inhibited the… CONTINUE READING
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