Effects of Cannabinoid Agonists and Antagonists on Sleep in Laboratory Animals.

  title={Effects of Cannabinoid Agonists and Antagonists on Sleep in Laboratory Animals.},
  author={Maureen L. Petrunich-Rutherford and Michael W. Calik},
  journal={Advances in experimental medicine and biology},
The cannabinoids are a family of chemical compounds that can be either synthesized or naturally derived. These compounds have been shown to modulate a wide variety of biological processes. In this chapter, the studies detailing the effects of cannabinoids on sleep in laboratory animals are reviewed. Both exogenous and endogenous cannabinoids generally appear to decrease wakefulness and alter rapid eye movement (REM) and non-REM sleep in animal models. In addition, cannabinoids potentiate the… 

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