Effects of Calcium on ACTH Stimulation of the Adrenal: Separation of Hormone Binding from Adenyl Cyclase Activation

@article{Lefkowitz1970EffectsOC,
  title={Effects of Calcium on ACTH Stimulation of the Adrenal: Separation of Hormone Binding from Adenyl Cyclase Activation},
  author={Robert J Lefkowitz and Jesse Roth and Ira Pastan},
  journal={Nature},
  year={1970},
  volume={228},
  pages={864-866}
}
CALCIUM is thought to be required for the binding of adrenal corticotrophic hormone (ACTH) to its cellular receptor1–5: in its absence, ACTH fails to stimulate steroidogenesis in the adrenal or lipolysis in adipose tissue1,2,6,7. The actions of other lipolytic hormones such as adrenaline and glucagon do not require calcium1–3. On the other hand, high calcium concentrations (>1 mM) inhibit the activation of adenyl cyclase by ACTH in subcellular particles from adipose and adrenal tissue8,9. The… CONTINUE READING

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